Best Researcher Award

Seyedeh Nasibeh Mousavikia — Mashhad University of Medical Sciences, Mashhad, Iran

Seyedeh Nasibeh Mousavikia is a researcher affiliated with Mashhad University of Medical Sciences whose scholarly work centers on medical physics, cancer biology, radiotherapy, molecular mechanisms of treatment resistance, and radiation responses. Her recent publications address colorectal cancer radiosensitivity, glioblastoma, cellular senescence, ferroptosis, exosomes, and purinergic signaling in cancer therapy.

Abstract

Seyedeh Nasibeh Mousavikia is a medical physics researcher whose publications examine cancer biology, radiotherapy, radioresistance, molecular signaling, and therapeutic responses. Her research includes investigations of colorectal cancer radiosensitivity, miR-16-5p, PI3K/AKT/mTOR signaling, radiation-induced senescence in glioblastoma, ferroptosis, exosomes, and P2X7 receptor biology. Her scholarly profile reflects interdisciplinary research connecting medical physics with molecular oncology and translational cancer research. Recent studies published with collaborators address mechanisms underlying treatment resistance and potential therapeutic strategies. These contributions provide a research foundation relevant to cancer treatment optimization, radiation response, molecular diagnostics, and emerging approaches for improving therapeutic sensitivity across cancer models and clinical contexts.[1][2]

Keywords

Medical physics, radiotherapy, radioresistance, colorectal cancer, glioblastoma, ferroptosis, exosomes, microRNA, miR-16-5p, PI3K/AKT/mTOR signaling, radiation-induced senescence, tumor microenvironment, cancer therapy, P2X7 receptor, DNA damage response, apoptosis, cellular signaling, radiosensitivity, molecular oncology, and therapeutic resistance. These terms reflect the principal scientific themes represented across her recent publications.[3]

Introduction

Seyedeh Nasibeh Mousavikia conducts research at the intersection of medical physics and cancer science, particularly examining biological mechanisms influencing radiotherapy response. Her recent work addresses molecular pathways, non-apoptotic cell death, cellular senescence, extracellular vesicles, and microRNA regulation, providing complementary perspectives on why malignant cells resist treatment and how sensitivity may be enhanced.[1][4]

Research Profile

Seyedeh Nasibeh Mousavikia’s research profile is characterized by collaboration across medical physics, molecular biology, cancer research, and radiotherapy. Her affiliations include the Department of Medical Physics and the Medical Physics Research Center at Mashhad University of Medical Sciences. Her publications demonstrate sustained interest in radiation response, tumor biology, signaling pathways, and therapeutic resistance mechanisms.[1][5]

Research Contributions

Seyedeh Nasibeh Mousavikia has contributed to studies investigating molecular determinants of cancer treatment response. Her research with collaborators has examined miR-16-5p regulation of cell-cycle genes, PI3K/AKT/mTOR signaling and colorectal cancer radiosensitivity, radiation-induced senescence in glioblastoma, ferroptosis as an alternative cell-death mechanism, exosomal biology, and P2X7-mediated radioresistance, collectively connecting molecular mechanisms with radiotherapy outcomes.[2][3]

Publications

Seyedeh Nasibeh Mousavikia has co-authored research and review articles including Identification and modulation of a PI3K/AKT/mTOR pathway-targeting microRNA in order to increase colorectal cancer cells radiosensitivity in vitro, Investigating miR-16-5p, Radiation-induced senescence in glioblastoma, Ferroptosis in cancer, Exosomes, and Unraveling the role of the P2X7 receptor in cancer radioresistance. These publications span molecular oncology, radiotherapy, and cancer biology.[1][3]

Research Impact

Seyedeh Nasibeh Mousavikia’s research contributes to understanding biological processes associated with cancer treatment resistance and radiation response. Her publications address pathways and mechanisms that may influence radiosensitivity, including microRNA regulation, cellular senescence, ferroptosis, extracellular vesicles, and purinergic signaling.[1]

Award Suitability

Seyedeh Nasibeh Mousavikia presents a research profile aligned with recognition in medical and health sciences through documented scholarly activity in medical physics, cancer biology, radiotherapy, and molecular oncology. Her publication record demonstrates collaborative investigation of contemporary cancer-treatment challenges, while her reported bibliometric indicators provide additional evidence of research dissemination.[2]

Conclusion

Seyedeh Nasibeh Mousavikia’s scholarly work demonstrates an interdisciplinary focus on medical physics and cancer research, with particular attention to radiotherapy response, molecular signaling, radioresistance, and emerging therapeutic mechanisms. Her recent publications provide evidence of active engagement with important questions in oncology and radiation biology, establishing a research profile relevant to contemporary medical and health-science scholarship.[1][4]

External Links

• ORCID Profile
• Scopus Author Profile
• BMC Cancer publication
• International Research Scientist Awards
• Google Scholar Profile

References

1. Mousavikia, S. N., Matin, M. M., Bahreyni Tossi, M. T., Aghaee-Bakhtiari, S. H., & Azimian, H. (2025). Identification and modulation of a PI3K/AKT/mTOR pathway-targeting microRNA in order to increase colorectal cancer cells radiosensitivity in vitro. BMC Cancer, 25, 1172.https://doi.org/10.1186/s12885-025-14501-5
2. Mousavikia, S. N., Matin, M. M., Bahreyni-Toossi, M. T., Aghaee-Bakhtiari, S. H., & Azimian, H. (2025). Investigating miR-16-5p: The Tumor Suppressor That Influences Cell Cycle Genes in Colorectal Cancer. Journal of Biomedical Physics and Engineering, 15(5), 451–458.https://doi.org/10.31661/jbpe.v0i0.2501-1874
3. Dehghan, N., Mousavikia, S. N., Qasempour, Y., & Azimian, H. (2024). Radiation-induced senescence in glioblastoma: An overview of the mechanisms and eradication strategies. Life Sciences, 359, 123218.https://doi.org/10.1016/j.lfs.2024.123218
4. Mousavikia, S. N., Matin, M. M., Bahreyni Tossi, M. T., & colleagues. (2025). Unraveling the role of the P2X7 receptor in cancer radioresistance: Molecular insights and therapeutic implications. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1872(3), 119910.https://doi.org/10.1016/j.bbamcr.2025.119910
5. Mousavikia, S. N., Darvish, L., Bahreyni Toossi, M. T., & Azimian, H. (2024). Exosomes: Their role in the diagnosis, progression, metastasis, and treatment of glioblastoma. Life Sciences, 350, 122743.https://doi.org/10.1016/j.lfs.2024.122743